What is GHK-Cu Serum 30 mL

GHK-Cu Serum 30 mL is a naturally occurring copper-complexed tripeptide studied in research for its powerful ability to promote tissue repair, collagen synthesis, and skin regeneration. It is intended exclusively for research use.

Regarding its chemical identity, GHK-Cu has a molecular formula of C14H24N6O4·Cu and a molecular weight of 404.9 g/mol. Its reported canonical sequence is Gly-L-His-L-Lys (complexed with Copper). A confirmed CAS number is not available in open primary reference sources and is therefore omitted.

Its synonyms include GHK-Cu.

Product for research use.

Mechanism of action of GHK-Cu

GHK-Cu acts as a signaling and carrier molecule for copper ions. It modulates the expression of over 4,000 human genes, upregulating genes associated with collagen and elastin production while downregulating genes involved in scar tissue formation and severe inflammation.

Pharmacokinetics and pharmacodynamics of GHK-Cu

When applied topically (as in a serum), it penetrates the stratum corneum and localizes in the dermal layers. Systemic absorption from topical administration is generally low, allowing it to exert highly concentrated local tissue repair effects.

Scientific evidence on GHK-Cu

The available evidence on GHK-Cu is preliminary and largely inconclusive, and should be interpreted with caution. The literature describes it as having been investigated for multiple indications in preclinical models.

Extensively backed by literature for its use in accelerating wound healing, reducing fine lines and wrinkles, stimulating hair growth, and improving overall skin elasticity and firmness in laboratory and dermatological models.

GHK-Cu applications in research

Ideal for (research context):
– In vitro and preclinical studies of its specific receptor pathways.
– Investigation of tissue repair, cell proliferation, and functional restoration in laboratory models.
– Comparative work with related peptides.

Not applicable for:
– clinical, diagnostic or therapeutic use.
– Any administration to humans or animals outside of an authorized research protocol.

Product for research use.

GHK-Cu protocols in preclinical studies

The literature consulted does not include numerical doses from studies that can be cited for GHK-Cu, so no trial schemes or quantities are specified.

The presentations of this product (30 mL Liquid Serum) refer only to the amount of lyophilized peptide per vial (or volume for liquids) and do not constitute a dosage recommendation. The design of any protocol, including concentrations and working volumes, is the responsibility of the researcher, based on their experimental objectives and the relevant primary literature.

Information provided exclusively for research purposes.

Reconstitution and manipulation of GHK-Cu

As a general guideline for laboratory handling, lyophilized peptides such as GHK-Cu are usually reconstituted with bacteriostatic water (sterile water with approximately 0.9% benzyl alcohol).

Add the solvent slowly down the side of the vial, letting it run over the lyophilized powder; avoid injecting the stream directly onto the powder.
Do not shake: gently rotate the vial until completely dissolved.
Adjust the solvent volume according to the desired working concentration, considering the 30 mL Liquid Serum contents of the vial.

These guidelines are for general technique and do not replace the internal procedures of each laboratory.

GHK-Cu Stability and Storage

As a standard laboratory handling procedure for peptides:

Freeze-dried (unreconstituted): This is the most stable form. It is best preserved by freezing and protecting it from moisture and light for long-term storage.
Reconstituted: once in solution, the peptide is less stable and must be kept refrigerated, being used within a short period; for extended storage, freezing in aliquots is usually preferred.
Avoid repeated freeze-thaw cycles, as they can degrade the peptide.

Given that the molecule is characterized by rapid enzymatic degradation in biological media, careful cold chain management is especially relevant.

Documented GHK-Cu security profile

The documented safety information in open sources for GHK-Cu is limited and should be interpreted with caution, also considering that it is research material and not for clinical use.

Topical application is generally well-tolerated in preclinical models. However, excessive application of copper peptides can theoretically lead to local copper toxicity or paradoxical skin degradation (the “copper uglies”), necessitating careful concentration management.

Formal contraindications and adverse event rates are not available in the consulted literature, so no figures are reported.

GHK-Cu in a comparative context

Compared to other cosmetic peptides like Matrixyl (which primarily targets collagen), GHK-Cu is unique in its ability to simultaneously deliver essential copper for enzymatic function while also exerting broad genetic modulation for overall tissue remodeling.

History and development of GHK-Cu

Discovered by Loren Pickart in 1973 in human plasma. It was noted that its levels decline significantly with age (from 200 ng/mL at age 20 to 80 ng/mL at age 60), making it a major focus of regenerative and anti-aging dermatological research.